The mass spectrometry platform of the State Key Laboratory of Elemento-organic Chemistry is based on a variety of mass spectrometry instruments. The platform provides users with various types of mass spectrometric analysis and test services, in addition to research platforms for relevant cooperative studies. The platform is considered as a major component of SKLEOC’s large-scale instrument platform. By now, the mass spectrometric analysis platform includes four large-scale mass spectrometry instruments and devices, including a Fourier transform ion cyclotron resonance mass spectrometer (7.0 Tesla FT-MS, Varian), a high-resolution GC MS (Q Exactive GC Orbitrap, Thermo), a high-resolution matrix-assisted laser desorption ionization time-of-flight mass spectrometry (Autoflex III TOF/TOF, Bruker), and a liquid chromatography-quadrupole mass spectrometer (LCQ Advantage, Thermo). The platform can make high-resolution mass spectrometric analysis and characterization of various types of synthetic intermediates, drug molecules, and bio-macromolecules, offering technical supports for synthetic organic chemistry, pesticide science, and biochemistry.
   
FTICR Mass Spectrometer
   
Manufacturer: Varian

Model: Varian 7.0T FTMS

Purchase date: May, 2006

Main specifications and technical indexes

The Fourier transform ion cyclotron resonance mass spectrometer (FTICR-MS) has the advantages of high resolution, high sensitivity, high precision, and high stability, etc. As for single-charge ionic compound, this instrument’s mass analysis range is up to 8000u, and the error is controlled within 4ppm.

Main functions and characteristics

Main fields of use: this instrument may be widely applied in the determination, analysis, and analysis of element composition, molecular mass and structure of organic compounds, drugs, polypeptides, proteins, glucides, coordination complexes, and synthetic polymers. As for undefined compounds, this instrument can determine its molecular mass precisely (error: within 2ppm), so as to confirm its element composition (molecular formula)..

Characteristic functions: this instrument is fitted with two independent ion sources, an ESI ionization source and a matrix assisted laser desorption ionization (MALDI) source. Both ESI and MALDI belong to the soft ionization technique. They are very suitable to test of chemical compounds with thermal instability such as proteins and polypeptides. In addition to supporting the test of cations and anions, this instrument may also be applied in tandem mass spectrometry (SORI and ECD) of single ions.

Main accessories and configuration

Precise mass calculation software and molecular formula search engine 
   
Contact: Shuqi Li

Email: shuqili@nankai.edu.cn

Tel.: 13612071523

    MALDI-TOF

Manufacturer: Bruker

Model: Autoflex III TOF/TOF 200

Purchase date: Oct. 2012

Main specifications and technical indexes:

1.    MALDI-TOF range: 500Da-300KDa

2.    Resolution: up to 20,000FWHM

3.    High sensitivity: minimum to 500 amol. S/N≥20:1

4.    Inner calibration, precision≤4ppm

Main functions and characteristics

Functions include:

1.    Determination of molecular mass

2.    Protein determination

3.    Polymer analysis

MALDI-TOF is characterized by its broad molecular mass determination range, strong anti-interference abilities, quick analyzing speed, and high convenience.

Main accessories and configuration

1.    UPS

2.    Computer

3.    Printer

4.    Various types of target holders and target plates

Contact: Sen Zhang

Email: Zhangsen06@126.com

Tel.: 137 5206 4015

LC-MS

Manufacture: Thermo Finnigan

Model: LCQ-Advantage

Purchase date: Jul. 2004

Main specifications and technical indexes:

Molecular mass test range: 50-2000

With ESI and APCI interfaces

Mass spectrometry/mass spectrometry sensitivity: 5pg/μL

A variety of scanning functions: Full-scale scanning, selected ion monitoring (SIM), and selected reaction monitoring (SRM). 

Main functions and characteristics

The instrument is applicable to qualitative and quantitative analysis of nonvolatile  with strong hydrophilicity organic compounds, thermally unstable organic compounds and bio-macromolecule. It can also be utilized in determination of molecular mass and        constitutional formula of undefined compounds.

Main accessories and configuration

ESI ionization source and APCI ionization source

Computer and printer

Contact: Sen Zhang

Email: Zhangsen06@126.com

Tel.: 13752064015