Topic: A Journey in Process Chemistry: Development of a Practical Synthesis of ERK Inhibitor and TAC Linker Drug
Spearker: Dr. Xin Linghu
Genentech, Inc. USA
Date: 3 July, 2017 (Monday)
Time: 16:00 p.m.
Venue: Academic Lecture Hall of the Shixian Building, NKU
Abstract：
Pharmaceutical process chemistry is a multidimensional discipline that transforms a sequence of reactions into a viable manufacturing process for a drug candidate. The high chemical complexity of modern pharmaceuticals presents a challenge to process chemists. In this presentation, process chemistry efforts on development of a practical synthesis of an ERK Inhibitor and TAC linker drug will be discussed. These two process chemistry case studies demonstrate both incremental and innovative changes to improve the synthetic efficiency of the original discovery chemistry sequence, delivering a large quantity of active pharmaceutical ingredients (APIs) in high purity in support of preclinical and clinical studies.
