Education

   (1) Hypervalent Iodine Chemistry

(2) Synthesis of Fluorinated Organic Compounds

(3) Synthesis of New Green Functional Surfactants

(4) C-H Bond Functionalization

(5) Synthesis of Heterocyclic Compounds

  Honors and Awards

Senior member of the Chinese Chemical Society

Member of the International Scientific Committee on Hypervalent Iodine Chemistry

Special member of the Society of Iodine Science (Japan)

Editorial board member of Modern Agrochemicals

Most Influential Letter published in Organic Letters (1999-2023), ACS Publications

Special Talent: Award for New Century Excellent Talents in University (Ministry of Education of China)

  Scientific Achievements

Our research group has specialized in hypervalent iodine chemistry, successfully developing novel reagents including AIBX, FPID, PISA, TFTI, AFBI, and TFNI through innovative design and synthesis.

 Selected Publications

1. “Direct Trifluoromethylthiolation of Terminal Alkynes Mediated by a Hypervalent Trifluoromethylthio-Iodine(III) Reagent; Boosting Effect of Fluorinated Alcohol” Y.-X. Cheng, X.-G. Yang, F.-H. Du, C. Zhang*, Green Chem., 2024, 26, 5914-5920.

2. “Fluorotrifluoromethylation of Alkenes Mediated by a Hypervalent Trifluoromethyl-Iodine(III) Reagent” M.-Q. Huang, C. Zhang*, Org. Lett., 2024, 26, 4158-4162.

3. “Solvent-Dependent Chemoselective Synthesis of Different Isoquinolinones Mediated by the Hypervalent Iodine(III) Reagent PISA” Z.-N. Hu, Y.-H. Wang , J.-B. Wu, Z. Chen, D. Hong , C. Zhang*, Beilstein J. Org. Chem., 2024, 20, 1914-1921.

4. “Preparation of Benziodazole-Triflate and Its Application as both 2-Iodobenzamido- and Triflate-Transfer Reagents” Y.-D. Li, F.-H. Du, J-J Li, J. Xu, Z-F Yang, S-S Li, C. Zhang*, Y-F. Du*, Chin. Chem. Lett., 2024, 110338.

5. “Halogen-Bonding-Mediated Synthesis of Amides and Peptides” M.-Q. Huang, J.-J. Li, C. Zhang*, Green Chem., 2023, 25, 9187-9193.

6. “Stereospecific Dehydroxytrifluoromethylthiolation of Alcohols Promoted by a Combination of Hypervalent Trifluoromethylthio-Iodine(III) Reagent and N Heterocyclic Carbene” X.-G. Yang, J.-J. Li, F.-H. Du, Y.-X. Cheng, C. Zhang*, Org. Lett., 2023, 25, 2964-2969.

7. “Chemoselective Cycloisomerization of O-Alkenylbenzamides via Concomitant 1,2-Aryl Migration/Elimination Mediated by Hypervalent Iodine Reagents” J. He, F.-H. Du, C. Zhang*, Y.-F. Du*, Comm. Chem., 2023, 6, 126-134.

8. “Accessing Aryl Azides via Copper Powder-Catalyzed Cross-Coupling of Arylboronic Acids with the Hypervalent Azido-Iodine Reagent ABZ(I)” Z. Yang, F.-H. Du, C. Zhang*, Y.-F. Du*, Org. Chem. Front. 2023, 10, 4131-4138.

9. “A General Method for One-Step Synthesis of Monofluoroiodane(III) Reagents Using Silver Difluoride” J. Ren, M.-C. Jia, F.-H. Du, C. Zhang*, Chin. Chem. Lett., 2022, 33, 4834-4837.

10. “Late-Stage Dehydroxyazidation of Alcohols Promoted by Trifunctional Hypervalent Azido-Iodine(III) Reagents” X.-G. Yang, F.-H. Du, J.-J. Li, C. Zhang*, Chem. Eur. J., 2022, 28, e202200272.

11. “Ring Expansion Fluorination of Unactivated Cyclopropanes Mediated by a New Monofluoroiodane(III) Reagent” J. Ren, F.-H. Du, M.-C. Jia, Z.-N. Hu, Z. Chen, C. Zhang*, Angew. Chem. Int. Ed., 2021, 60, 24171-24178.

12. “Singlet Oxygen Generation from a Water-Soluble Hypervalent Iodine(V) Reagent AIBX and H2O2: An Access to Artemisinin” H.-J. Shen, Z.-N. Hu, C. Zhang*, J. Org. Chem., 2021, 87, 3885-3894.

13. “Recent Advances and the Prospect of Hypervalent Iodine Chemistry” X.-G. Yang, Z.-N. Hu, M.-C. Jia, F.-H. Du, C. Zhang*, Synlett, 2021, 32, 1289-1296.

14. “Electrophilic Hypervalent Trifluoromethylthio-Iodine(III) Reagent” X.-G. Yang, K. Zheng, C. Zhang*, Org. Lett., 2020, 22, 2026-2031.

15. “A Benziodoxole-Based Hypervalent Iodine(III) Compound Functioning as a Peptide Coupling Reagent” L.-J. Qiu, D. Liu, K. Zheng, M.-T. Zhang* and C. Zhang*, Front. Chem., 2020, 8, 183-196.

16. “Double Dehydrogenation of Carbocyclic-Dicarbonyl Compounds: Koser's Reagent can do What Iodine(V) Reagents can” S.-S. Liu, L. Wang, Y.-N. Duan, A. Yu*, C. Zhang*, Sci. China Chem., 2019, 62, 597-601.

17. “Redetermination of the Structure of a Water-Soluble Hypervalent Iodine(V) Reagent AIBX and Its Synthetic Utility in the Oxidation of Alcohols and Synthesis of Isoxazoline N Oxides” H.-J. Shen, Y.-N. Duan, K. Zheng, C. Zhang*, J. Org. Chem., 2019, 84, 14381-14393.

18. “Synthetic Application of Water-Soluble Hypervalent Iodine Reagents in Aqueous Media” Y.-C. Han, C. Zhang*, Tetrahedron Lett., 2018, 59, 3052-3064.

19. “Water-Soluble Hypervalent Iodine(III) Having an I−N Bond. A Reagent for the Synthesis of Indoles” H.-D. Xia, Y.-D. Zhang, Y.-H. Wang, C. Zhang*, Org. Lett., 2018, 20, 4052-4056.

20. “Recyclable Hypervalent-Iodine-Mediated Solid-Phase Peptide Synthesis and Cyclic Peptide Synthesis” D. Liu, Y.-L. Guo, J. Qu, C. Zhang*, Beilstein J. Org. Chem., 2018, 14, 1112-1119.

21. “Hypervalent-Iodine-Mediated Formation of Epoxides from Carbon(sp2)−Carbon(sp3 ) Single Bonds” S. Jiang, T.-S. Yan, Y.-C. Han, L.-Q. Cui, X.-S. Xue*, and C. Zhang*, J. Org. Chem., 2017, 82, 11691-11702.

22. “Hypervalent-Iodine-Mediated Ring-Contraction Monofluorination Affording Monofluorinated Five-Membered Ring-Fused Oxazolines” Y.-C. Han, Y.-D. Zhang, Q. Jia, J. Cui, C. Zhang*, Org. Lett., 2017, 19, 5300-5303.

23. “Recyclable Hypervalent-Iodine-Mediated Dehydrogenative Cyclopropanation Under Metal-Free Conditions” Y.-N. Duan, Z. Zhang, C. Zhang*, Org. Lett., 2016, 18, 6176-6179.

24. “Iodosobenzene-Mediated Direct and Efficient Oxidation of β-dicarbonyls to Vicinal Tricarbonyls Catalyzed by Iron(III) Salts” J. Cui, Y.-N. Duan, J. Yu, C. Zhang*, Org. Chem. Front., 2016, 3, 1686-1690.

25. “Practical Peptide Synthesis Mediated by a Recyclable Hypervalent Iodine Reagent and Tris(4-methoxyphenyl)phosphine” C. Zhang*, S.-S. Liu, B. Sun, J. Tian, Org. Lett., 2015, 17, 4106-4109.