Education   

1995-1997   Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA. Postdoctoral associate (with Prof. Ru-Yu Chen)  

1992-1995    Department of Chemistry, Zhongshan University Received Ph.D. degree in June, 1995 (with Prof. Jing-Yu Su)

1987-1990    Institute of Elemento-organic Chemistry，Nankai University,   Tianjin, CHINA，Received M.S.degree in June, 1990 (with Prof. Qing-lan Xie)  

1983-1987    Department of Chemistry, Anhui Normal University, Wu hu, CHINA. Received B. Sc. Degree in June, 1987

(1)     Natural products. especially ecological function natural products  

(2)     Design and synthesis of Agrochemicals

(3)     Plant Allelopathy

Honors & Awards 
2008    Award for china society of plant protection

Selected Publications

1. Guo-shuai Li, Yi-Fei Yan,Peng-Fei Zhang, Xiao-Hua Xu* and Zhong Jin *  Palladium-Catalyzed meta-Selective C−H Functionalization by Noncovalent H-Bonding Interaction  ACS Catal. 2021, 10460−10466.

2. Yun-Yao Kang, Zhi-Li Pang, Niu-Niu Xu, Fang-Jie Chen, Zhong Jin* and Xiao-Hua Xu* Strigolactone Analogues Derived from Dihydroflavonoids as Potent Seed Germinators for the Broomrapes J. Agric. Food Chem. 2020,68，11077−11087.

3. Bo Wang, Yu Zhou, Niu-Niu Xu,  Xiu-Fang Xu* , Xiao-Hua Xu* , and Zhong Jin* Palladium(II)-Catalyzed Remote meta-C−H Functionalization of Aromatic Tertiary Amines  Org. Lett. 2019, 21, 1885−1889.

4. Shu-Guang Xie, Sen Li, Wen-Qian Ma, Xiao-Hua Xu* and Zhong Jin *Chelation-directed remote meta-C–H functionalization of aromatic aldehydes and ketones Chem. Commun., 2019, 55, 12408—12411.

5. Jing-Jing Chen, Jian-Cong Xu, Yu Zhou, Shu-Guang Xie, Feng Gao, Xiu-Fang Xu,  Xiao-Hua Xu,* and Zhong Jin* Sequential ortho-C−H and ipso-C−O Functionalization Using a Bifunctional Directing Group  Org. Lett. 2019, 21, 7928−7932.

6. Jian-Cong Xu, Jing-Jing Chen, Feng Gao, Shu-Guang Xie, Xiao-Hua Xu,*Zhong Jin* and Jin-Quan Yu*,Sequential Functionalization of meta-C−H and ipso-C−O Bonds of Phenols J. Am. Chem. Soc. 2019, 141, 1903−1907.

7. Kang Lei，Pan Li，Xue-Fang Yang, Shi-Ben Wang, Xue-Kun Wang， Xue-Wen Hua,Bin Sun,Lu-Sha Ji,and Xiao-Hua Xu* ,Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)- pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action J. Agric. Food Chem. 2019, 67, 10489−10497.

8. Jian-Cong Xu, Yang Liu, Jin-Ling Zhang, Xiao-Hua Xu* and Zhong Jin * Palladium-catalyzed enantioselective C(sp2)–H arylation of ferrocenyl ketones enabled by a chiraltransient directing group Chem. Commun., 2018, 54, 689—692.

9. Jian-Cong Xu, Yang Liu, Ying Wang, Ya-Juan Li, Xiao-Hua Xu,* and Zhong Jin* Pd-Catalyzed Direct ortho-C−H Arylation of Aromatic Ketones Enabled by aTransient Directing Group Org. Lett. 2017, 19, 1562−1565.

10. Bo Wang, Yuan-Yuan Tao, Qi-Sheng Liu, Na Liu  Zhong Jin, and Xiao-Hua Xu * Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful Algae Mar. Drugs 2017, 15, 247 ,1 – 9.

11. Yang Liu, Jian-Cong Xu, Jin-Ling Zhang, Xiaohua Xu,* and Zhong Jin* Intramolecular Direct C−H Arylation via a Metallocenic Radical Pathway: Stereospecific Approach to Planar-Chiral Ferrocenes Org. Lett. 2017, 19, 5709−5712.

12. Yang Liu, Kang Lei, Na Liu, Dong-Wei Sun, Xue-Wen Hua,Indium-Mediated Intramolecular Reaction of N-2-Iodobenzoyl)-azabenzonorbornadienes: A General Access to Dihydrobenzo[c]phenanthridinones J.Org. Chem. 2016, 81, 5495−5503.

13. Kang Lei, Dong-Wei Sun, Xue-Wen Hua, Yuan-Yuan Tao, Xiao-Hua Xu, Chui-Hua Kong. Synthesis, Fungicidal Activity, and Structure–Activity Relationships of 3-Benzoyl-4-Hydroxylcoumarin Derivatives.  Pest Manag. Sci. 2016,72,172–178.

14. Kang Lei, Xue-Wen Hua, Yuan-Yuan Tao, Yang Liu, Na Liu, Yi Ma, Yong-Hong Li, Xiao-Hua Xu, Chui-Hua Kong. Discovery of (2-Benzoylethen-1-ol)-Containing 1, 2-Benzothiazine Derivatives as Novel 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Inhibiting-Based Herbicide Lead Compounds.  Bioorg. Med. Chem. 2016, 24, 92–103.

15. Cui Guo, Dong-Wei. Sun, Suang. Yang, Shen-Jie.Mao, Xiao-Hua. Xu,* Shou-Fei Zhu,* and Qi-Lin Zhou*Iridium-Catalyzed Asymmetric Hydrogenation of 2‑Pyridyl Cyclic Imines: A Highly Enantioselective Approach to Nicotine Derivatives  J. Am. Chem. Soc. 2015, 137, 90−93.

Patents

1. 徐效华,吕培，谢龙观，孙立冬  

   2-氯烟酸合成方法

   ZL 200810152155.1，专利申请日，2008/10/08 授权日期：2010/12/29

2. 谢龙观，徐效华，魏志刚等

   噻唑化合物在淡水藻杀藻方面应用

   中国发明专利, ZL201210112982.4  申请日:2012/04/18，授权日期：2014/11/29

3. 徐效华，郭翠，谢龙观，朱守非

   一种植物源农药烟碱和毒藜碱的不对称合成方法

   中国发明专利, 专利申请号：201410616324.8 申请日2014/11/04，授权日期：2016/09/07

4. 徐效华，陶圆圆，刘奇声，刘娜，谢龙观

   2-( 1-羟乙基)、2-乙酰基噻唑-4-甲酰胺类化合物及应用

   中国发明专利, 专利申请号：专利申请号：201410616325.2 申请日2014/11/04  授权日期：2017/10/31

5. 徐效华，刘奇声，陶园园，谢龙观

   2-(1-胺基-乙基)-N-苯基噻唑-4-甲酰胺化合物水溶性成盐方法及其在杀灭淡水藻方面的应用

   中国发明专利, 申请号：201410091119.4 申请日：2014/03/13  授权日期：2016/04/06

6. 徐效华，雷康，孙东伟，谢龙观

   4-羟基-3-苯甲酰基-1-烷基-2,1-苯并噻嗪-2,2-二氧化物衍生物及其应用

   中国发明专利, 申请号201510016488.1  申请日期2015/1/14  授权日期：2017/06/14

7. 徐效华，雷康，孙东伟，谢龙观

   4-羟基-3-苯甲酰基-1-烷基-2,1-苯并噻嗪-2,2-二氧化物衍生物及其应用

   中国发明专利, 申请号201510053120.2 申请日期2015/1/28  授权日期：2017/02/01

8. 徐效华，孙东伟，雷康，谢龙观

   黄酮类天然化合物Frutinones A,B,C的合成

   中国发明专利, 申请号201510032508.2 申请日期2015/1/21  授权日期：2017/05/24


Commercialization of Scientific and Research Findings

发明专利ZL 200810152155.1， 2-氯烟酸合成方法，农药中间体2-氯烟酸连续化合成方法成果转让3家企业，获得经费60万。