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元素有机化学国家重点实验室英文版

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徐效华   教授    

Prof. Xiao-Hua Xu (X.-H. Xu)        

Tel: 86-22-23793769     

E-mail: xiaohuaxu@nankai.edu.cn


 

Education   

1995-1997   Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA. Postdoctoral associate (with Prof. Ru-Yu Chen)  

1992-1995    Department of Chemistry, Zhongshan University Received Ph.D. degree in June, 1995 (with Prof. Jing-Yu Su)

1987-1990    Institute of Elemento-organic Chemistry,Nankai University,   Tianjin, CHINA,Received M.S.degree in June, 1990 (with Prof. Qing-lan Xie)  

1983-1987    Department of Chemistry, Anhui Normal University, Wu hu, CHINA. Received B. Sc. Degree in June, 1987




Academic Career                                

2002-2014   Vice Director, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

2002-            Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

2002-            Postdoctoral associate, Chinese University of HongKong (with Prof. Henry N. C. WONG).

1997-2002    Associate Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.


Research Areas

(1)     Natural products. especially ecological function natural products  

(2)     Design and synthesis of Agrochemicals

(3)     Plant Allelopathy


Honors & Awards 
2008    Award for china society of plant protection


Selected Publications

  1. Guo-shuai Li, Yi-Fei Yan,Peng-Fei Zhang, Xiao-Hua Xu* and Zhong Jin *  Palladium-Catalyzed meta-Selective C−H Functionalization by Noncovalent H-Bonding Interaction  ACS Catal. 2021, 10460−10466.

  2. Yun-Yao Kang, Zhi-Li Pang, Niu-Niu Xu, Fang-Jie Chen, Zhong Jin* and Xiao-Hua Xu* Strigolactone Analogues Derived from Dihydroflavonoids as Potent Seed Germinators for the Broomrapes J. Agric. Food Chem. 2020,6811077−11087.

  3. Bo Wang, Yu Zhou, Niu-Niu Xu,  Xiu-Fang Xu* , Xiao-Hua Xu* , and Zhong Jin* Palladium(II)-Catalyzed Remote meta-C−H Functionalization of Aromatic Tertiary Amines  Org. Lett. 2019, 21, 1885−1889.

  4. Shu-Guang Xie, Sen Li, Wen-Qian Ma, Xiao-Hua Xu* and Zhong Jin *Chelation-directed remote meta-C–H functionalization of aromatic aldehydes and ketones Chem. Commun., 2019, 55, 12408—12411.

  5. Jing-Jing Chen, Jian-Cong Xu, Yu Zhou, Shu-Guang Xie, Feng Gao, Xiu-Fang Xu,  Xiao-Hua Xu,* and Zhong Jin* Sequential ortho-C−H and ipso-C−O Functionalization Using a Bifunctional Directing Group  Org. Lett. 2019, 21, 7928−7932.

  6. Jian-Cong Xu, Jing-Jing Chen, Feng Gao, Shu-Guang Xie, Xiao-Hua Xu,*Zhong Jin* and Jin-Quan Yu*,Sequential Functionalization of meta-CH and ipso-CO Bonds of Phenols J. Am. Chem. Soc. 2019, 141, 1903−1907.

  7. Kang LeiPan LiXue-Fang Yang, Shi-Ben Wang, Xue-Kun Wang Xue-Wen Hua,Bin Sun,Lu-Sha Ji,and Xiao-Hua Xu* ,Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)- pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action J. Agric. Food Chem. 2019, 67, 10489−10497.

  8. Jian-Cong Xu, Yang Liu, Jin-Ling Zhang, Xiao-Hua Xu* and Zhong Jin * Palladium-catalyzed enantioselective C(sp2)–H arylation of ferrocenyl ketones enabled by a chiraltransient directing group Chem. Commun., 2018, 54, 689—692.

  9. Jian-Cong Xu, Yang Liu, Ying Wang, Ya-Juan Li, Xiao-Hua Xu,* and Zhong JinPd-Catalyzed Direct ortho-CH Arylation of Aromatic Ketones Enabled by aTransient Directing Group Org. Lett. 2017, 19, 15621565.

  10. Bo Wang, Yuan-Yuan Tao, Qi-Sheng Liu, Na Liu  Zhong Jin, and Xiao-Hua Xu * Algicidal Activity of Bacillamide Alkaloids and Their Analogues against Marine and Freshwater Harmful Algae Mar. Drugs 2017, 15, 247 ,1 9.

  11. Yang Liu, Jian-Cong Xu, Jin-Ling Zhang, Xiaohua Xu,* and Zhong Jin* Intramolecular Direct CH Arylation via a Metallocenic Radical Pathway: Stereospecific Approach to Planar-Chiral Ferrocenes Org. Lett. 2017, 19, 57095712.

  12. Yang Liu, Kang Lei, Na Liu, Dong-Wei Sun, Xue-Wen Hua,Indium-Mediated Intramolecular Reaction of N-2-Iodobenzoyl)-azabenzonorbornadienes: A General Access to Dihydrobenzo[c]phenanthridinones J.Org. Chem. 2016, 81, 5495−5503.

  13. Kang Lei, Dong-Wei Sun, Xue-Wen Hua, Yuan-Yuan Tao, Xiao-Hua Xu, Chui-Hua Kong. Synthesis, Fungicidal Activity, and Structure–Activity Relationships of 3-Benzoyl-4-Hydroxylcoumarin Derivatives.  Pest Manag. Sci. 2016,72,172–178.

  14. Kang Lei, Xue-Wen Hua, Yuan-Yuan Tao, Yang Liu, Na Liu, Yi Ma, Yong-Hong Li, Xiao-Hua Xu, Chui-Hua Kong. Discovery of (2-Benzoylethen-1-ol)-Containing 1, 2-Benzothiazine Derivatives as Novel 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Inhibiting-Based Herbicide Lead Compounds.  Bioorg. Med. Chem. 2016, 24, 92–103.

  15. Cui Guo, Dong-Wei. Sun, Suang. Yang, Shen-Jie.Mao, Xiao-Hua. Xu,* Shou-Fei Zhu,* and Qi-Lin Zhou*Iridium-Catalyzed Asymmetric Hydrogenation of 2Pyridyl Cyclic Imines: A Highly Enantioselective Approach to Nicotine Derivatives  J. Am. Chem. Soc. 2015, 137, 90−93.


Patents

  1. 徐效华,吕培,谢龙观,孙立冬  

    2-氯烟酸合成方法

    ZL 200810152155.1,专利申请日,2008/10/08 授权日期:2010/12/29

  2. 谢龙观,徐效华,魏志刚等

    噻唑化合物在淡水藻杀藻方面应用

    中国发明专利, ZL201210112982.4  申请日:2012/04/18,授权日期:2014/11/29

  3. 徐效华,郭翠,谢龙观,朱守非

    一种植物源农药烟碱和毒藜碱的不对称合成方法

    中国发明专利, 专利申请号:201410616324.8 申请日2014/11/04,授权日期:2016/09/07

  4. 徐效华,陶圆圆,刘奇声,刘娜,谢龙观

    2-( 1-羟乙基)、2-乙酰基噻唑-4-甲酰胺类化合物及应用

    中国发明专利, 专利申请号:专利申请号:201410616325.2 申请日2014/11/04  授权日期:2017/10/31

  5. 徐效华,刘奇声,陶园园,谢龙观

    2-(1-胺基-乙基)-N-苯基噻唑-4-甲酰胺化合物水溶性成盐方法及其在杀灭淡水藻方面的应用

    中国发明专利, 申请号:201410091119.4 申请日:2014/03/13  授权日期:2016/04/06

  6. 徐效华,雷康,孙东伟,谢龙观

    4-羟基-3-苯甲酰基-1-烷基-2,1-苯并噻嗪-2,2-二氧化物衍生物及其应用

    中国发明专利, 申请号201510016488.1  申请日期2015/1/14  授权日期:2017/06/14

  7. 徐效华,雷康,孙东伟,谢龙观

    4-羟基-3-苯甲酰基-1-烷基-2,1-苯并噻嗪-2,2-二氧化物衍生物及其应用

    中国发明专利, 申请号201510053120.2 申请日期2015/1/28  授权日期:2017/02/01

  8. 徐效华,孙东伟,雷康,谢龙观

    黄酮类天然化合物Frutinones A,B,C的合成

    中国发明专利, 申请号201510032508.2 申请日期2015/1/21  授权日期:2017/05/24


  9. Commercialization of Scientific and Research Findings

    发明专利ZL 200810152155.1, 2-氯烟酸合成方法,农药中间体2-氯烟酸连续化合成方法成果转让3家企业,获得经费60万。


 

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