Education   

1982-1987   Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, CHINA. Received Ph.D. degree in December, 1987 (with Prof. Yao-Zeng Huang). 

1978-1982   Department of Chemistry, Lanzhou University, Lanzhou, CHINA. Received B.Sc. degree in June, 1982.  

Academic Career  

1999-           Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

1997-1999   Professor, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, CHINA.

1996-1997   Associate professor, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, CHINA.

1994-1996   Postdoctoral associate, Department of Chemistry, Trinity University, Texas, USA. (with Prof. Michael P. Doyle).

1992-1994   Postdoctoral associate, Institute of Organic Chemistry, Basel University, Basel, SWITZERLAND

                    (with Prof. Andreas Pfaltz).

1990-1991   Postdoctoral associate, Max-Planck Institute of Polymer Science, Mainz, GERMANY (with Prof. Klaus Müllen).

1988-1990   Postdoctoral associate, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, CHINA 

                    (with Prof. Zheng-Hua Zhu).

(1)     Synthetic methodology

(2)     Asymmetric catalysis

(1)     Organometallic chemistry

(1)     Synthesis of biologically active compounds and chiral drugs

Honors & Awards  

2021    National Outstanding Professional and Technical Talents

2019    Research Achievement Award of Nankai University

2019    First Prize of National Natural Science Award

2018    Future Science Prize---The Physical Science Prize

2018    Chemistry Contribution Award (Chinese Chemical Society and CNPC)

2017    Boehringer-Ingelheim Lecturer at California Institute of Technology

2016     Gest Professor, Shanghai Institute of Technology

2014    National Outstanding Scientist (China Association for Science and Technology)

2014    Novartis Lecturer (the Scripps Research Institute)

2013    Fellow of Royal Society of Chemistry

2012    Prize of Chiral Chemistry (Chinese Chemical Society)

2009    Academician of Chinese Academy of Sciences

2007    JSPS Fellowship Award (Japan Society for the Promotion of Science)

2006    Yao-Zeng Huang Prize of Organometallics (Chinese Chemical Society)

2005    Prize for Creation in Organic Synthesis (Chinese Chemical Society, Division of Organic Chemistry)

1999    Cheung Kong Scholar (Ministry of Education of China)

1997    Award for Outstanding Young Scientists (National Natural Science Foundation of China)

Professional Memberships 

2019-  Associate editor, Chemical Journal of Chinese University

2018-  Associate editor, CCS Chemistry

2016-  Member, Editorial Advisory Board of Helvetica Chimica Acta

2016-  Editorial Board of National Science Review

2014-  Member, Editorial Advisory Board of Tetrahedron & Tetrahedron Lett.

2014-  Member, Advisory Editorial Board of J. Org. Chem.

2012-  Member, Advisory Editorial Board of Asian J. Org. Chem.

2011-  Member, Editorial Board of Advanced Synthesis & Catalysis

2010-  Member, Advisory Editorial Board of Chemical Science

2009-  Member, Editorial Board of Series of Topics in Organometallic Chemistry

2008-  Member, Editorial Board of Journal of Molecular Catalysis A: Chemical

2007-  Member, Editorial Board of Chinese Journal of Organic Chemistry

Selected Publications

1. Lei Cheng, Ming-Ming Li, Mao-Lin Li, Li-Jun Xiao, Jian-Hua Xie, Qi-Lin Zhou*, Nickle-catalyzed regio- and enantioselective hydroarylation of 1,3-dienes with indoles, CCS Chem. 2021, 3, 3260-3267.

2. Wei-Min Feng, Tian-Yu Li, Li-Jun Xiao*, Qi-Lin Zhou*, Nickel-catalyzed intramolecular hydroalkenylation of imines, Org Lett. 2021, 23, 7900-7904.

3. Tian-Yuan Zhao, Ke Li, Liang-Liang Yang, Shou-Fei Zhu, Qi-Lin Zhou*, Nickel-catalyzed desymmertrizing cyclization of 1,6-dienes to construct quaternary stereocenters, Org. Lett. 2021, 23, 3814-3817.

4. Liang-Liang Yang, Jing Ouyang, Hui-Na Zou, Shou-Fei Zhu*, Qi-Lin Zhou*, Enantioseletive insertion of alkynyl carbenes into Si−H bonds: an efficient access to chiral propargylsilanes and allenylsilanes, J. Am. Chem. Soc. 2021, 143, 17, 6401-6406.

5. Xiao-Gen Li, Qi-Lin Zhou*, Manganese-catalyzed selective hydrogenative cross-coupling of nitriles and amines to form secondary imines, Adv. Synth. Catal. 2021, 363, 1-6.

6. Chao Fan, Qi-Lin Zhou*. Nickel-catalyzed group transfer of radicals enables hydrocyanation of alkens and alkynes, Chem. Catalysis, 2021, 1, 1-12.

7. Ming-Ming Li, Lei Cheng, Li-Jun Xiao, Jian-Hua Xie, Qi-Lin Zhou*, Palladium-catalyzed asymmetric hydrosulfonylation of 1,3-dienes with sulfonyl hydrazides, Angew, Chem, Int, Ed. 2021, 60, 2948-2951.

8. Ji-Min Yang, Feng-Kai Guo, Yu-Tao Zhao, Qiao Zhang, Ming-Yao Huang, Mao-Lin Li, Shou-Fei Zhu*, Qi-Lin Zhou*, Insertion of alkylidiene carbenes into B-H bonds, J. Am. Chem. Soc. 2020, 142, 20924-20929.

9. Liu-Yang Pu, Fan Yang, Ji-Qiang Chen, Ying Xiong, Huai-Yu Bin, Jian-Hua Xie*, Qi-Lin Zhou*, Enantioselective total syntheses of pentacyclic homeproaporphine alkaloids, Org. Lett. 2020, 22, 7526-7530.

10. Liang-Liang Yang, Declan Evans, Bin Xu, Wen-Tao Li, Mao-Lin Li, Shou-Fei Zhu*, K. N. Houk*, Qi-Lin Zhou*, Enantioselective diarylcarbene insertion into Si−H bonds induced by electronic properties of the carbenes, J. Am. Chem. Soc. 2020, 142, 12394-12399.

11. Feng-Hua Zhang, Fa-Jian Zhang, Mao-Lin Li, Jian-Hua Xie and Qi-Lin Zhou*, Enantioselective hydrogenation of dialkyl ketones, Nat. Catal 2020, 3, 621-627.

12. Mao-Lin Li, Jin-Han Yu, Yi-Hao Li, Shou-Fei Zhu*, Qi-Lin Zhou*, Highly enantioselective carbene insertion into N−H Bonds of aliphatic amines, Science 2019, 366, 990-994.

13. Lei Cheng, Ming-Ming Li, Biao Wang, Li-Jun Xiao,* Jian-Hua Xie, Qi-Lin Zhou*, Nickel-catalyzed hydroalkylation and hydroalkenylation of 1,3-dienes with hydrazones, Chem. Sci. 2019, 10, 10417-10420.

14. Xin-Yang Lv, Chao Fan, Li-Jun Xiao*, Jian-Hua Xie, Qi-Lin Zhou*, Ligand-enabled nickel-catalyzed enantioselective hydroarylation of styrenes and 1,3-dienes with arylboronic acids, CCS Chem. 2019, 1, 328-334.

15. Wen Che, Yu-Zhen Li, Jin-Chi Liu, Shou-Fei Zhu, Jian-Hua Xie, and Qi-Lin Zhou*, Stereodiverse iterative synthesis of 1,3-polyol arrays through asymmetric catalytic hydrogenation. Formal total synthesis of (–)-cyanolide A, Org. Lett. 2019, 21, 2369-2373.

16. Chao Fan, Xin-Yang Lv, Li-Jun Xiao,* Jian-Hua Xie, and Qi-Lin Zhou*, Alkenyl exchange of allylamines via nickel(0)-catalyzed C−C bond cleavage, J. Am. Chem. Soc. 2019, 141, 2889-2893.

17. Lei Cheng, Ming-Ming Li, Li-Jun Xiao*, Jian-Hua Xie, and Qi-Lin Zhou*, Nickel(0)-catalyzed hydroalkylation of 1,3-dienes with simple ketones, J. Am. Chem. Soc. 2018, 140, 11627-11630.

18. Ji-Min Yang, Yu-Tao Zhao, Zi-Qi Li, Xue-Song Gu, Shou-Fei Zhu*, and Qi-Lin Zhou*, Gold-catalyzed oxidative coupling of terminal alkynes and borane adducts: efficient synthesis of α-boryl ketones, ACS Catal. 2018, 8, 7351-7355.

19. Ke Li, Mao-Lin Li, Qi Zhang, Shou-Fei Zhu*, and Qi-Lin Zhou*, Highly enantioselective nickel-catalyzed intramolecular hydroalkenylation of N- and O-tethered 1,6-dienes to form six-membered heterocycles, J. Am. Chem. Soc. 2018, 140, 7458-7461.

20. Wen Che, Danyang C. Wen, Shou-Fei Zhu*, and Qi-Lin Zhou*, Iterative synthesis of polydeoxypropionates based on iridium-catalyzed asymmetric hydrogenation of α-substituted acrylic acid, Org. Lett. 2018, 20, 3305-3309.

21. Li-Jun Xiao, Chao-Yue Zhao, Lei Cheng, Bo-Ya Feng, Wei-Min Feng, Jian-Hua Xie, Xiu Fang Xu*, Qi-Lin Zhou*, Nickel(0)-catalyzed hydroalkenylation of imines with styrene and its derivatives, Angew. Chem. Int. Ed. 2018, 57, 3396-3400.

22. Li-Jun Xiao, Lei Cheng, Wei-Min Feng, Mao-Lin Li, Jian-Hua Xie, Qi-Lin Zhou*, Nickel(0)-catalyzed hydroarylation of styrenes and 1,3-dienes with organoboron compounds, Angew. Chem. Int. Ed. 2018, 57, 461-464.

23. Guo-Peng Wang, Meng-Qing Chen, Shou-Fei Zhu*, Qi-Lin Zhou*, Enantioselective Nazarov cyclization of indole enones cooperatively catalyzed by Lewis acids and chiral Brønsted acids, Chem. Sci. 2017, 8, 7197-7202.

24. Min-Jie Zhou, Shou-Fei Zhu, Qi-Lin Zhou*, Copper-catalyzed Mannich-type oxidative β-functionalization of tertiary amines, Chem. Commun. 2017, 53, 8770-8773.

25. Shou-Fei Zhu*, Qi-Lin Zhou*, Iridium-catalyzed asymmetric hydrogenation of unsaturated carboxylic acids, Acc. Chem. Res. 2017, 50, 988-1001.

26. Huan Xu, Yi-Pan Li, Yan Cai, Shou-Fei Zhu,* Qi-Lin Zhou*, Highly enantioselective copper- and iron-catalyzed intramolecular cyclopropanation of indoles, J. Am. Chem. Soc. 2017, 139, 7697-7700.

27. Ji-Min Yang, Zi-Qi Li, Mao-Lin Li, Qiao He, Shou-Fei Zhu*, Qi-Lin Zhou*, Catalytic B−H bond insertion reaction using alkynes as carbene precursors, J. Am. Chem. Soc. 2017, 139, 3784-3789.

28. Mao-Lin Li, Shuang Yang, Xun-Cheng Su, Hui-Ling Wu, Liang-Liang Yang, Shou-Fei Zhu*, Qi-Lin Zhou*, Mechanism studies of Ir-catalyzed asymmetric hydrogenation of unsaturated carboxylic acids, J. Am. Chem. Soc. 2017, 139, 541-547.

29. Shuang Yang, Wen Che, Hui-Ling Wu, Shou-Fei Zhu*, Qi-Lin Zhou*, Neutral iridium catalysts with chiral phosphine-carboxy ligands for asymmetric hydrogenation of unsaturated carboxylic acids, Chem. Sci. 2017, 8, 1977-1980.

30. Deng-Hui Bao, Xue-Song Gu, Jian-Hua Xie,* Qi-Lin Zhou*, Iridium-catalyzed highly efficient asymmetric hydrogenation of racemic b-keto lactams via dynamic kinetic resolution, Org. Lett. 2017, 19, 118-121.

31. Xiao-Guang Song, Yuan-Yuan Ren, Shou-Fei Zhu*, Qi-Lin Zhou*, Enantioselective copper-catalyzed intramolecular N‒H bond insertion: Synthesis of chiral 2-carboxy tetrahydroquinolines, Adv. Syn. Catal. 2016, 358, 2366-2370.

32. Ming-Lei Yuan, Jian-Hua Xie, Shou-Fei Zhu, Qi-Lin Zhou*, Deoxygenative hydrogenation of amides catalyzed by a well-defined iridium pincer complex, ACS Catal. 2016, 6, 3665-3669.

33. Jing Hou, Ming-Lei Yuan, Jian-Hua Xie, Qi-Lin Zhou*, Nickel-catalyzed hydrocarboxylation of alkynes with formic acid, Green Chem. 2016, 18, 2981-2984.

34. Yang Liu, Li-Jie Cheng, Hai-Tao Yue, Wen Che, Jian-Hua Xie*, Qi-Lin Zhou, Divergent enantioselective synthesis of hapalindole-type alkaloids using catalytic asymmetric hydrogenation of a ketone to construct the chiral core structure, Chem. Sci. 2016, 7, 4725-4729.

35. Liu-Yang Pu, Ji-Qiang Chen, Mao-Lin Li, Yao Li, Jian-Hua Xie*, Yao Li, Qi-Lin Zhou, Enantioselective construction of chiral 2,3-cis-dimethyl dihydrobenzofuran with an all-carbon quaternary center: An efficient approach to (+)/(-)-PI-220 and (+)-3-epi-furaquinocin C, Adv. Synth. Catal. 2016, 358, 1229-1240.

36. Han Lin, Li-Jun Xiao, Min-Jie Zhou, Hong-Ming Yu, Jian-Hua Xie*, Qi-Lin Zhou*, An enantioselective approach to (-)-hamigeran B via catalytic asymmetric hydrogenation of racemic ketone to assemble the chiral core framework, Org. Lett. 2016, 18, 1434-1437.

37. Yan-Bo Yu, Lei Cheng, Yi-Pan Li, Yue Fu, Shou-Fei Zhu*, Qi-Lin Zhou*, Enantioselective iridium-catalyzed hydrogenation of β,β-dialkyl substituted nitroalkenes, Chem. Commun. 2016, 52, 4812-4815.

38. L.-J. Xiao, X.-N. Fu, M.-J. Zhou, J.-H. Xie, L.-X. Wang, X.-F. Xu*, Q.-L. Zhou*, Nickel-catalyzed hydroacylation of styrenes with simple aldehydes: Reaction development and mechanistic insights, J. Am. Chem. Soc. 2016, 138, 2957-2960.

39. Q.-L. Zhou, Transition-metal catalysis and organocatalysis: Where can progress be expected? Angew. Chem. Int. Ed. 2016, 55, 5352-5353 (Editorial).

40. J. Hou, J.-H. Xie, Q.-L. Zhou*, Palladium-catalyzed hydrocarboxylation of alkynes with formic acid, Angew. Chem. Int. Ed. 2015, 54, 6302-6305.

41. S. Song, S.-F. Zhu, L.-Y. Pu, Q.-L. Zhou*, Iridium-catalyzed enantioselective hydrogenation of unsaturated heterocyclic acids, Angew. Chem. Int. Ed. 2013, 52, 6072-6075.

42. X.-G. Song, S.-F. Zhu, X.-L. Xie, Q.-L. Zhou*, Highly enantioselective copper-catalyzed intramolecular phenolic O‒H bond insertion: An efficient synthesis of chiral 2-carboxy dihydro-benzofurans, dihydrobenzopyrans and tetrahydrobenzooxepines, Angew. Chem. Int. Ed. 2013, 52, 2555-2558.

43. S. Song, S.-F. Zhu, Y.-B. Yu, Q.-L. Zhou*, Carboxy-directed asymmetric hydrogenation of 1,1-diarylethenes and 1,1-dialkylethenes, Angew. Chem. Int. Ed. 2013, 52, 1556-1559.

44. S.-F. Zhu, Y.-B. Yu, S. Li, L.-X. Wang, Q.-L. Zhou*, Enantioselective hydrogenation of α-substituted acrylic acids catalyzed by iridium complexes with chiral spiro aminophosphine ligands, Angew. Chem. Int. Ed. 2012, 51, 8872-8875.

45. S.-F. Zhu, Q.-L. Zhou*, Transition-metal-catalyzed enantioselective heteroatom–hydrogen bond insertion reactions, Acc. Chem. Res. 2012, 45, 1365-1377.