Education

2004-2010，Department of Bioorganic Chemistry, Uppsala University, SWEDEN. Received PhD degree in April, 2010

 (with Prof. Jyoti Chattopadhyaya).

2001-2004，Institute of Elemento-Organic Chemistry, Nankai University, CHINA. Received MS degree in June, 2004

 (with Prof. Zhen Xi).

1997-2001，Department of Chemistry, Nankai University, CHINA. Received BSc Degree in June, 2001.

Academic Career

Research Areas

(1) Chemical biology of biological macromolecules (nucleic acids and proteins).

(2) Medical chemistry.

2019 Young and Middle-aged Leading Personnel in Science and Technology Innovation of Tianjin City.

1. M. Ren, M. M. Greenberg*, C. Z. Zhou*, Participation of histones in DNA damage and repair within nucleosome core particles: Mechanism and applications. Acc. Chem. Res. 2022, DOI: 10.1021/acs.accounts.2c00041.

2. H. Wang, X. Shan, M. Ren, M. Shang, C. Z. Zhou*, Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis. Nucleic Acids Res. 2021, 49, 12306-12319.

3. M. Ren, M. Shang, H. Wang, Z. Xi, C. Z. Zhou*, Histones participate in base excision repair of 8-oxodGuo by transiently cross-linking with active repair intermediates in nucleosome core particles. Nucleic Acids Res. 2021, 49, 257-268.

4. H. Wang, C. Zang, M. Ren, M. Shang, Z. Wang, X. Peng, Q. Zhang, X. Wen, Z. Xi, C. Z. Zhou*, Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS). Sci. Rep. 2020, 10, 15385.

5. Y. Zhang, C. Zang, G. An, M. Shang, Z. Cui, G. Chen, Z. Xi, C. Z. Zhou*, Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones. Nat. Commun. 2020, 11, 1015.

6. Q. Li, J. Chen, M. Trajkovski, Y. Zhou, C. Fan, K. Lu, P. Tang, X. Su, J. Plavec, Z. Xi, C. Z. Zhou*， 4′-Fluorinated RNA: Synthesis, structure, and applications as a sensitive 19F NMR probe of RNA structure and function. J. Am. Chem. Soc. 2020, 142, 4739-4748.

7. C. Zang, H. Wang, T. Li, Y. Zhang, J. Li, M. Shang, J. Du, Z. Xi, C. Z. Zhou*, A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates. Chem. Sci. 2019, 10, 8973-8980.

8. F. M. Guo, Z. K. Yue, M. Trajkovski, X. P. Zhou, D. Cao, Q. Li, B. F. Wang, X. Wen, J. Plavec*, Q. Peng*, Z. Xi, and C. Z. Zhou*, Effect of ribose conformation on RNA cleavage via internal transesterification. J. Am. Chem. Soc. 2018, 140, 11893-11897.

9. F. C. Li, Y. Q. Zhang, J. Bai, M. M. Greenberg, Z. Xi, C. Z. Zhou*, 5-Formylcytosine yields DNA-protein crosslinks in nucleosome core particles. J. Am. Chem. Soc. 2017, 139, 10617-10620. [Featured in JACS Spotlights: J. Am. Chem. Soc. 2017, 139, 11629].

10. Y. Q. Zhang, X. P. Zhou, Y. H. Xie, M. M. Greenberg, Z. Xi, and C. Z. Zhou*, Thiol specific and tracelessly removable bioconjugation via Michael addition to 5‑methylene pyrrolones. J. Am. Chem. Soc. 2017, 139, 6146−6151。