EDUCATION

ACADEMIC CAREER

 RESEARCH AREAS

(1)    Frustrated Lewis Pairs

(2)   Transition Metal-Catalyzed Organic Transformations

HONORS AND AWARDS

2012    Research of Excellence Award, University of Maryland
2012    Millard ard and Lee Alexander Graduate Fellowship in Chemistry, University of Maryland

SELECTED PUBLICATIONS 

1. Xiao-Chen Wang, Wei Gong, Li-Zhen Fang, Ru-Yi Zhu, Suhua Li, Keary M. Engle, Jin-Quan Yu*“Ligand-Enabled meta-C–H Activation Using a Transient Mediator”Nature, 2015, 519, 334–338.

2.   Ru-Yi Zhu, Jian He, Xiao-Chen Wang, Jin-Quan Yu* “Ligand-Promoted Alkylation of C(sp3)–H and C(sp2)–H Bonds” J. Am. Chem. Soc., 2014,136 (38), 13194–13197.

3. Xichen Xu, Xiaochen Wang, Yuxiao Liu, Michael P Doyle* “Enantioselective Carbonyl-ene Reactions Catalyzed by Chiral Cationic Dirhodium(II,III) Carboxamidates”J. Org. Chem., 2014,79 (24), 12185-12190.

4. Ling Chu, Xiao-Chen Wang, Curtis E Moore, Arnold L. Rheingold, and Jin-Quan Yu* “Pd-catalyzed Enantioselective C–H Iodination: Asymmetric Synthesis of Chiral Diarylmethylamines” J. Am. Chem. Soc., 2013,135 (44), 16344–16347.

5. Xiao-Chen Wang, Yi Hu, Samuel Bonacorsi, Yang Hong, Richard Burrell, and Jin-Quan Yu* “Pd(II)-catalyzed C–H Iodination Using Molecular I₂ as the Sole Oxidant” J. Am. Chem. Soc., 2013, 135 (28), 10326–10329.

6. Yu Qian, Xinfang Xu, Xiaochen Wang, Peter Y. Zavalij, Wenhao Hu and Michael P. Doyle* “Rhodium(II) and Copper(II) Catalyzed Reactions of Enoldiazoacetates with Nitrones. Metal Carbene versus Lewis Acid Directed Pathways”Angew. Chem., Int. Ed.2012, 51 (24), 5900–5903.

7. Xiaochen Wang, Quentin M. Abrahams, Peter Y. Zavalij and Michael P. Doyle* “Highly Regio- and StereoselectiveDirhodiumVinylcarbene-induced Nitrone Cycloaddition with Subsequent Cascade Carbenoid Aromatic Cycloaddition/N-O Cleavage and Rearrangement” Angew. Chem., Int. Ed. 2012, 51 (24), 5907–5910.

8. Xiaochen Wang, Xinfang Xu, Peter Y. Zavalij and Michael P. Doyle* “Asymmetric Formal [3+3]-Cycloaddition Reactions of Nitrones with Electrophilic Vinylcarbene Intermediates”J. Am. Chem. Soc., 2011, 133 (41), 16402–16405.

9. Xiaochen Wang, CarolinWeigl, and Michael P. Doyle* “Solvent Enhancement of Reaction Selectivity: A Unique Property of Cationic Chiral DirhodiumCarboxamidates” J. Am. Chem. Soc., 2011, 133 (24),9572–9579.

10.  Hong Chen,* Song Zuo, Xiaochen Wang, Xiaowei Tang, Ming Zhao, Yanling Lu, and Liting Chen  “Synthesis of 4β-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents.”  Eur. J. Med. Chem., 2011, 46, 4709-4714.

11. Xiaochen Wang, Zhuoyan Li and Michael P. Doyle* “Barriers to Enantiocontrol in Lewis Acid Catalyzed Hetero-Diels–Alder Reactions” Chem. Commun.,2009, 5612-5614.

12. Jian-Hua Xie, Sheng Liu, Wei-Ling Kong, Wen-Ju Bai, Xiao-Chen Wang, Li-Xin Wang and Qi-Lin Zhou*　“Highly Enantioselective and Diastereoselective Synthesis of Chiral Amino Alcohols by Ruthenium-Catalyzed Asymmetric Hydrogenation of α-Amino Aliphatic Ketones”　J. Am. Chem. Soc., 2009, 131 (12), 4222–4223.