研究方向及取得的突出成果

核酸化学及抗肿瘤抗病毒药物研究

                                               

主要学术兼职      

曾兼任国家自然科学基金委化学部主任 (1999-2006)，国务院学位委员会学科评议组药学学科召集人 (1998-2008)，中国药学会副理事长 (1998-2006)。IUPAC, Organic & Biomolecular Chemistry委员会委员 (Titular Member,2006-2009)，英国皇家化学会Fellow (FRSC)，亚洲药化学会主席 (1998-1999)。现兼任“Organic & Biomolecular Chemistry”，“ChemMedChem” “Medicinal Research Review”和“Current Topics of Medicinal Chemistry”编委，《中国药物化学》杂志主编，《高等学校化学学报》副主编。中科院上海有机所生命有机国家重点实验室学术委员会副主任，中科院上海药物所新药研究国家重点实验室学术委员会副主任，南开大学农药与元素有机国家重点实验室学术委员会主任等。        

 

荣誉与奖励

1990年日本Hoshi University 名誉博士学位；        

1991年保罗•杨森-吴阶平医学药学奖；        

1992年美国密苏里-堪薩斯大学Edgar-Snow Professorship；        

1992年国际药联 (FIP) Corlocon奖 (Tokyo)；        

1997年国家教委科技进步二等奖；        

1999年国家教育部科技进步一等奖；        

1999年何梁、何利科技进步奖；        

2000年国际药联(FIP) Millennium Pharmaceutical Scientists Award (San Francisco, USA)；        

2002年教育部自然科学二等奖；        

2004年国家自然科学二等奖；

2008年南开大学杨石先讲座教授；        

2008年北京大学国华杰出学者奨；        

2009年亚洲药学会Nagai-Hisamitsu杰出科学家奖。

 

Selected Publications

1.  Synthesis and biological evaluation of novel neamine–nucleoside conjugates potentially targeting to RNAs. Yanli Xu, Hongwei Jin, Zhenjun Yang, Liangren Zhang, Lihe Zhang, Tetrahedron, 2009, 65, 5228-5239.

2.  Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs. Huang Huang, Renping Qiao, Deyao Zhao, Tong Zhang, Youxian Li, Fan Yi, Fangfang Lai, Junmei Hong, Xianfeng Ding, Zhenjun Yang, Lihe Zhang, Quan Du, and Zicai Li, Nucleic Acids Res., 2009, 37 (22), 7560-7569.

3.   A method for detecting and preventing negative RNA interference in preparation of lentiviral vectors for siRNA delivery. Demin Zhou, Jing Zhang, Cuiying Wang, J. Bliesath, Qiuchen He, Dehua Yu, Lihe Zhang and F. Wong-Staal, RNA, 2009, 15, 732-740.

4.  CD38/cADPR/Ca²⁺ Pathway Promotes Cell Proliferation and Delays Nerve Growth Factor-induced Differentiation in PC12 Cells. Jianbo Yue, Wenjie Wei, Connie M. C. Lam, Yong-Juan Zhao, Min Dong, Liang-Ren Zhang, Li-He Zhang, and Hon-Cheung Lee, J. Biol. Chem. 2009, 284, 29335-29342.

5.  Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca2+-mobilizing activity in T-lymphocytes. Lingjun Li,Cornelia C. Siebrands, Zhenjun Yang, Liangren Zhang, Andreas H. Guse and Lihe Zhang, Org. Biol. Chem. 2010, 8, 1843-1848.

6.  Trifluoromethylated cyclic-ADP-ribose mimic: synthesis of 8-trifluoromethyl-N1-[(5''-O-phosphorylethoxy)methyl]-5'-O-phosphorylinosine-5￠,5￠￠-cyclicpyrophosphate (8-CF3-cIDPRE) and its calcium release activity in T cells, Min Dong, Tanja Kirchberger, Xiangchen Huang, Zhen Jun Yang,Liang Ren Zhang, Andreas H. Guse and Li He Zhang, Org. Biol. Chem., 2010, 8, 4705-4715.

7.  Concise synthesis of novel acyclic analogues of cADPR with an ether chain as the northern moiety, Huimin Wu, Zhenjun Yang, Liangren Zhang and Lihe Zhang, New J. Chem., 2010, 34, 956–966.

8.   A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge, N. Qi,za K. Jung,M. Wang, L. X. Na Z. J. Yang, L. R. Zhang, A. H. Guse and L. H. Zhang, Chem. Commun., 2011, 47, 9462–9464.

9.  Design, synthesis and biological characterization of novel inhibitors of CD38, Min Dong,Yuan-Qi Si,Shuang-Yong Sun,Xiao-Ping Pu, Zhen-Jun Yang, Liang-Ren Zhang, Li-He Zhang, Fung Ping Leung, Connie Mo Ching. Lam, Anna Ka Yee Kwong, Jianbo Yue, Yeyun Zhou, Irina A. Kriksunov, Quan Hao and Hon Cheung Lee, Org. Biomol. Chem., 2011, 9, 3246.

10.  Design, synthesis and biological evaluation of novel non-covalent inhibitors of human CD38 NADase,Yi Zhou, Kai Yiu Ting, Connie Mo Ching Lam, Anna Ka Yee Kwong, Jie Xia, Hongwei Jin, Zhenming Liu,Liangren Zhang, Hon Cheung Lee and Lihe Zhang, ChemMedChem., 2011, DOI: 10.1002/cmdc.200.

11.  Strand antagonism in RNAi: an explanation of differences in potency between intracellularlyexpressed siRNA and shRNA ,Xin Jin, Tingting Sun, Chuanke Zhao, Yongxiang Zheng, Yufan Zhang, Weijing Cai, Qiuchen He, Kaz Taira, Lihe Zhang and Demin Zhou, Nucleic Acids Research, 2011, 1–10,doi:10.1093/nar/gkr927.

12.  Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38, Anna Ka Yee Kwong, Zhe Chen,Hong Min Zhang, Fung Ping Leung,Connie Mo Ching Lam, Kai Yiu Ting, Liangren Zhang,Quan Hao, Li-He Zhang, and Hon Cheung Lee, Biochemistry, 2011 in press.