Education

2000-2003             The Research Institute of Elemento-organic Chemistry, Tianjin, CHINA. Received Ph.D. Degree in June, 2003. 
          (with Prof. Q.-L. Zhou)

1994-1997             The Research Institute of Elemento-organic Chemistry, Tianjin, CHINA. Received M. Sc. Degree in June, 1997. 
          (with Prof. T.-L. Liu)

1990-1992             Department of Chemistry, Sichuan Teachers College,Nanchong, CHINA. Received B. Sc. Degree in June, 1992.

1988-1990              Department of Chemistry, Neijiang Teachers College,Neijian, CHINA.

Academic Career

2008-                       Associate Professor and Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

2007-2008               Postdoctoral Fellow, Department of Chemistry and Biochemistry, University of Maryland, U.S.A. 
           (with Prof. Micheal P. Doyle).

2003-2007               Assistant and Associate Professor, The Research Institute of Elemento-organic Chemistry,Tianjin, CHINA.

1997-2000               Engineer, Chengdu Di’ao Pharmaceutical company, Chengdu, CHINA.

Research Areas

(1)  Homogeneous catalysis, especially the development of new chiral ligands, catalysts and catalytic systems for asymmetric reactions.

(2)  Natural products synthesis, especially the development of new asymmetric catalysis methods for the synthesis of biologically active  natural products and structural analogues.

Honors& Awards

2013              Award for National Outstanding Young Scientist (National Natural Science Foundation of China)

2012              Thieme Chemistry Journals Award

2008              New Century Excellent Talents Project (Ministry of Education, China)

2007              Tianjin Natural Science Award (The First-Rank)

Representative Achievements

(1)  Design and synthesis of several types of novel chiral tridentate spiro pyridine-, oxazole-, and thioether-aminophosphine ligands based on chiral “privileged” spirobiindane backbone, and find their chiral spiro iridium catalysts are highly efficient and enantioselective for the asymmetric hydrogenation of a wide range of substrates including ketones, b-ketoesters, and a,b-unsaturated ketones.

(2)  Development of a range of highly efficient asymmetric hydrogenations via kinetic/dynamic kinetic resolution, providing new efficient methods for the enantioselective synthesis of structurally diverse chiral alcohols, especially those with contiguous stereocenters.

(3)  Establishment of several efficient strategies featuring asymmetric ketone hydrogenations for constructing polycyclic chiral structures bearing quaternary stereocenters, and achievement of the enantioselective total synthesis of many natural products including galantamine, gracilamine, goniomitine, and mulinane diterpenoids.

Selected Publications

1. Huai-Yu Bin, Li Cheng, Xiong Wu, Chang-Liang Zhu, Xiao-Hui Yang,* Jian-Hua Xie,* Qi-Lin Zhou. Asymmetric Hydrogenation of Exocyclic g,d-Unsaturated b-Ketoesters to Functionalized Chiral Allylic Alcohols via Dynamic Kinetic Resolution. Chem. Sci. 2021, 12, 7793-7799.

2. Qian-Kun Zhao, Xiong Wu, Lin-Ping Li, Fan Yang, Jian-Hua Xie,* Qi-Lin Zhou. Asymmetric Hydrogenation of β-Aryl Alkylidene Malonate Esters: Installing an Ester Group Significantly Increases the Efficiency. Org Lett. 2021, 23, 1675-1680.

3. Liu-Yang Pu, Fan Yang, Ji-Qiang Chen, Ying Xiong, Huai-Yu Bin, Jian-Hua Xie,* and Qi-Lin Zhou.* Enantioselective Total Syntheses of Pentacyclic Homeproaporphine Alkaloids. Org. Lett. 2020, 22, 7526-7530.

4. Huai-Yu Bin, Ke Wang, Dan Yang, Xiao-Hui Yang, Jian-Hua Xie,* Qi-Lin Zhou. Scalable Enantioselective Total Synthesis of (‐)‐Goniomitine. Angew. Chem., Int. Ed. 2019, 58, 1174-1177.

5. Yun-Ting Liu, Lin-Ping Li, Jian-Hua Xie*, Qi-Lin Zhou, Divergent Asymmetric Total Synthesis of Mulinane Diterpenoids, Angew. Chem. Int. Ed. 2017 56, 12708-12711.

6. Xiao-Dong Zuo, Shu-Min Guo, Rui Yang, Jian-Hua Xie*, Qi-Lin Zhou*, Bioinspired Enantioselective Synthesis of Crinine-type Alkaloids via Iridium-Catalyzed Asymmetric Hydrogenation of Enones, Chem. Sci. 2017, 8, 6202-6206.

7. Xiao-Hui Yang, Hai-Tao Yue, Na Yu, Yi-Pan Li, Jian-Hua Xie*, Qi-Lin Zhou*. Iridium-Catalyzed Asymmetric Hydrogenation of Racemic α-Substituted Lactones to Chiral Diols, Chem. Sci. 2017, 8, 1811-1814.

8. Yang Liu, Li-Jie Cheng, Hai-Tao Yue, Wen Che, Jian-Hua Xie*, Qi-Lin Zhou. Divergent Enantioselective Synthesis of Hapalindole-type Alkaloids Using Aatalytic Asymmetric Hydrogenation of a Ketone to Construct the Chiral Core Structure, Chem. Sci. 2016, 7, 4725-4729.

9. Deng-Hui Bao, Hui-Ling Wu, Chao-Lun Liu, Jian-Hua Xie*, Qi-Lin Zhou*, Development of Chiral Spiro P-N-S Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of β-Alkyl-β-Ketoesters, Angew. Chem. Int. Ed. 2015, 54, 8791-8794.

10. Xiao-Hui Yang, Ke Wang, Shou-Fei Zhu, Jian-Hua Xie*, Qi-Lin Zhou*. Remote Ester Group Leads to Efficient Kinetic Resolution of Racemic Aliphatic Alcohols via Asymmetric Hydrogenation, J. Am. Chem. Soc. 2014, 136, 17426–17429.

11. Xiao-Hui Yang, Jian-Hua Xie*, Wei-Peng Liu, Qi-Lin Zhou*, Catalytic Asymmetric Hydrogenation of δ-Ketoesters: Highly Efficient Approach to Chiral 1,5-Diols, Angew. Chem. Int. Ed. 2013, 52, 7833-7836.

12. Chong Liu, Jian-Hua Xie*, Ya-Li Li, Ji-Qiang Chen, Qi-Lin Zhou*, Asymmetric Hydrogenation of α,α'-Disubstituted Cycloketones via Dynamic Kinetic Resolution: An Efficient Construction of Chiral Diols with Three Contiguous Stereocenters, Angew. Chem. Int. Ed. 2013, 52, 593–596.